Flow Chemistry & Applications to the Pharmaceutical Industry

Highlighted articles: Last flow review published by Andrew R. Bogdan and Amanda W. Dombrowski entitled Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

It is an interesting summary with many examples of how flow chemistry was applied to the synthesis of  important molecules for the pharmaceutical industry. Thanks for this interesting review.

Enjoy the reading!!!

Abstract: The field of flow chemistry has garnered considerable attention over the past 2 decades. This Perspective highlights many recent advances in the field of flow chemistry and discusses applications to the pharmaceutical industry, from discovery to manufacturing. From a synthetic perspective, a number of new enabling technologies are providing more rationale to run reactions in flow over batch techniques. Additionally, highly automated flow synthesis platforms have been developed with broad applicability across the pharmaceutical industry, ranging from advancing medicinal chemistry programs to self-optimizing synthetic routes. A combination of simplified and automated systems is discussed, demonstrating how flow chemistry solutions can be tailored to fit the specific needs of a project.

Full text https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01760